I always thought that general knowledge is the best anti-virus out there. Besides that Spybot's Tea Times is just amazing. It lets you accept or deny registry changes, BHOs, startup, pretty much everything. The only bad thing is that the average computer user doesn't know when or when not to accept a change. I have been using it for about 2 years now and hasn't let me down yet.
Also the last time I used Avast it slowed my computer down dramatically, and seeing as I love to play games this is a negative.
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